Abstract
Summary
Ovariectomized virgin female mice kept at a high environmental temperature (35°C) had a decreased ability to respond to progesterone and estrone injections with mammary lobule-alveolar growth. This same high temperature did not inhibit this response in animals injected with a pituitary extract containing the mammogenic lobule-alveolar growth factor which directly stimulates mammary gland growth. Thus the anterior pituitaries of animals kept at a high environmental temperature have a decreased ability to respond to the stimulus of progesterone plus estrone with the secretion of the mammogenic lobule-alveolar growth factor.
Get full access to this article
View all access options for this article.