Abstract
Summary
Our studies indicate that it is difficult to secure cerebral infection when the virus of St. Louis encephalitis is introduced into the intestinal tract. Nevertheless one definite infection did occur after intraintestinal inoculation. We feel the experimental procedure ruled out the nasal route of infection. Some degree of humoral immunity was produced in mice both by intragastric and intraintestinal inoculation. Only two animals survived the subsequent intracerebral injection of 100 lethal doses of virus, showing that only rarely is adequate protection against infection provided by intragastric or intraintestinal virus inoculations.
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