Abstract
Summary
The spectacle eye syndrome in rats has been produced very consistently by the inclusion of egg white in a synthetic diet which allows good growth in the absence of egg white. Pantothenic acid at levels up to 100 γ per day does not prevent the onset of this condition. Corn oil and pyridoxine or the combination of the two are without effect. Inositol has neither a preventative nor a curative action under these conditions. A biotin concentrate at a level of 2γ of biotin per day is specific for the prevention and cure of this syndrome. The cure is first noticeable after 5 days and complete restoration of the hair results after 2-3 weeks of treatment. A definite weight gain is noted with rats receiving the biotin concentrates.
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