Abstract
Summary
The intravenous injection of trypsin in doses of 1 to 2 mg per kilo in dogs, or 3 to 7 mg per kilo in rabbits produces a varying degree of incoagulability of the blood. As the addition of similar concentrations of trypsin to blood in vitro does not produce this incoagulability, the latter appears to be an indirect effect. The addition of suitable amounts of protamine restores the coagulability to normal, indicating that the coagulation defect is due to heparin, presumably liberated in vivo from various tissues such as the liver.
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