Glucuronic Acid Production in vitro by Liver Slices from Rats Fed Dimethylaminoazobenzene (Butter Yellow)

Abstract

Conclusions

1. The ability of rat liver slices to conjugate borneol with glucuronic acid in vitro is not impaired, even when marked cirrhosis and malignant degeneration of the liver are produced, by the feeding of dimethylaminoazobenzene. 2. The glucuronide excretion of rats fed dimethylaminoazobenzene is initially somewhat higher than in the control animals. However, after 100 days of dimethylaminoazobenzene feeding, the rate is less than 25 Jo of that seen initially.