Abstract
Conclusion
Biotin-deficiency is brought about in the chick reared on a heated ration of low biotin content (O.1γ/g). This deficiency is produced in the absence of dietary egg white which is essential for the development of the avitaminosis in the rat. Deficiency symptoms are completely cured by administration of crystalline biotin methyl ester. The chick can be used in a quantitative biological assay of biotin.
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