Abstract
Summary
Each of 7 local anaesthetics derived from p-aminobenzoic acid partially or completely blocked the in vitro bacteriostatic effect of sulfapyridine upon a strain of B. coli grown in a simple medium. None of 9 local anaesthetics not derived from p-aminobenzoic acid displayed any antagonism to the sulfapyridine. Each of 3 local anaesthetics derived from p-aminobenzoic acid blocked the bacteriostatic effect of sulfathiazole on B. coli and Staphylococcus aureus. None of 3 local anaesthetics not derived from p-aminobenzoic acid displayed any antagonism to the sulfathiazole.
Get full access to this article
View all access options for this article.