Abstract
Conclusions
p-Nitrobenzoic and m-nitrobenzoic acids are readily reduced to amino-compounds by tissue suspensions. o-Nitrobenzoic acid, in contrast, is reduced to only a small extent by tissue suspensions.
When p-nitrobenzoic acid or m-nitrobenzoic acid is administered to rats only a small fraction of the dose is excreted in the urine in the reduced form, the remainder is present in a state of oxidation above the amine. The reduced fraction is conjugated to a high degree. o-Nitrobenzoic acid is also reduced by rats; an appreciable amount of free amine is recoverable from the urine.
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