Abstract
Summary and Conclusions
Pellets of estrone were implanted in the subcutaneous tissues, the spleen, and the transplanted ligated spleen, respectively, of groups of normal adult male rats. At the time of implantation of the pellet the right testis was removed in half the number of animals of each group. Marked atrophy occurred in the testes and related genital organs when the pellet was present in the subcutaneous tissues or in the transplanted ligated spleen. No changes occurred in these organs when the pellet was present in the normally situated spleen, indicating that when the absorbed estrone passes through the liver of normal adult male rats before reaching the organs it specifically affects, it is inactivated.
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