Abstract
Summary
Anestrus occurred as long as a pellet of testosterone propionate was present in the subcutaneous tissues of normal female rats. No significant changes occurred in the estrous cycles of normal adult female rats when pellets of testosterone propionate were implanted in the spleen in which the normal portal circulation was intact. When the blood from the spleen containing a pellet of testosterone propionate entered the systemic circulation without passing through the liver, estrus was inhibited.
The technical assistance of Ruth Helmuth is gratefully acknowledged.
Get full access to this article
View all access options for this article.