Effect of Pituitary Growth Hormone on the Thymectomized Rat ∗

Abstract

Summary

1. The growth in body weight of female rats thymectomized at the age of 8 days and followed to the age of 6 months is the same as that of sham operated littermate controls. 2. The response of hypophysectomized-thymectomized female rats to a preparation of the pituitary growth hormone is the same as that of similarly treated hypophysectomized littermate controls which had been subjected to a sham thymectomy. 3. The response of plateaued thymectomized female rats with intact pituitaries to a potent growth hormone preparation of the anterior pituitary is the same as that of sham operated littermate controls. 4. Under the conditions of this experiment, therefore, the thymus gland was not necessary either for the growth in weight of otherwise normal animals or for the marked increase in body weight produced by the administration of anterior pituitary growth hormone.