Comparative Therapeutic Efficiency of Sulfapyridine and Sulfathiazole in Mice Infected with Pneumococcus Types II and III

Abstract

Summary

Studies of the toxicity disclose that sulfathiazole administered per os to rabbits is less toxic than sulfapyridine. On the other hand, administered the same way to mice sulfapyridine appeared to be less toxic than sulfathiazole. It is obvious that the absorption and elimination, and the resulting toxicity of the drug depend upon the species of animal used. In Types II and III pneumococcus infection, the therapeutic effect of sulfapyridine is superior to that of sulfathiazole, based on the oral dose only and with no blood level determinations.