Use of Colchicine in Detecting Hormonal Effects on Vaginal Epithelium of Menstruating and Castrate Women. ∗

Abstract

Conclusions

Colchicine, by topical application in vaginal pessaries, permits the detection of the growth stimulating effects of estrogens, and progesterone in combination with estrogens, on the vaginal epithelium of menopausal castrates. In menstruating women, this technic demonstrates clearly the proliferative effect of these hormones of endogenous origin during both the follicular and premenstrual phases of the cycle.