Abstract
Summary
Small pellets of estradiol benzoate implanted locally into the uterus produced fibromyomatous tumors in 9 out of 12 guinea pigs (75%) after intervals varying from 32 to 150 days. Estrone in the same concentration did not produce tumors in 2 animals. From the findings made in 2 additional animals, it appears that androgen may have a tendency to limit the extent to which the estrogen is able to produce these tumors.
We wish to thank Miss Jane Smelser and Miss Anne Hammet for preparing the histological material and Mr. George Smelser for his advice and assistance.
We are indebted to Prof. B. P. Watson and to Dr. Carl Bachman for their help and criticism in preparing this material, and to Mr. Fred Roseberry for his careful drawings. The hormones used in these experiments were furnished by the courtesy of Mr. Robert Mautner of the Ciba Pharmaceutical Products, Incorporated.
Get full access to this article
View all access options for this article.