Abstract
Summary
Ligation of the common bile duct of rats prior to or 20 hours after the injection of L7 organisms delayed the onset of arthritis, and the subsequent degree of joint involvement up to 12 days' time was markedly diminished. However, when duct ligation was performed after the onset of arthritis there was no effect upon the course of the disease. Since rat arthritis induced by the injection of hemolytic streptococci was not influenced by bile duct ligation, it seems probable that the effect of obstructive jaundice on the development and severity of L7 arthritis in rats was due to the bile solubility of the L7 organisms.
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