Abstract
Summary
Guinea pigs were found to show a tolerance to delvinal sodium [5-ethyl-5-(l-methyl-1-butenyl) barbituric acid] on repeated administration of large doses of the drug. The average length of sleep dropped from 127.3 to 48.2 minutes following 8 semi-weekly injections of the drug, while the average length of hypnosis dropped from 191.9 to 104.1 minutes. The average weight of the guinea pigs increased from 250 to 380 g, which was more than a 50% increase in weight.
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