The Effect of Renin on the Cardiac Output

Abstract

Summary

1. The cardiac output per minute of intact dogs anesthetized with 2.5 to 3.5 mg of morphine sulphate per kilogram was determined according to the Fick principle before and after the intravenous injection of renin and of tyramine. 2. On using a dosage of renin and of tyramine sufficient to give a good pressor effect, the cardiac output was not found to be significantly changed.

I wish to thank Drs. B. S. Oppenheimer and B. Friedman for their interest and criticism of this work.