Abstract
We have reported 1 that diodrast (D) and inulin plasma clearances are markedly reduced in hypophysectomized dogs. It was not determined whether the low D clearance was due to a low renal plasma flow (RPF) or to a diminished renal extraction of D, or to both. The present paper reports on the effects of “simple” hypophysectomy (section of stalk with removal of dependent gland) and of complete hypophysectomy (includes destruction of median eminence) on D plasma clearance, plasma D extraction, RPF, tubular extraction of D, maximum tubular excretory rate for D (D Tm), inulin clearance, filtration fraction and blood volume. It also reports on the question of glomerular intermittence after hypophysectomy, with the finding that intermittence does not occur. Since no certain difference in effects of simple and of complete hypophysectomy was observed on any of the processes studied, no distinction will be made in the present report: the effects are apparently due to loss of anterior lobe, although further observations are required before a final statement can be made. Six dogs have been studied; pre-hypophysectomy observations of most of the processes studied were made on the same animals.
Diodrast plasma clearance. In 15 post-hypophysectomy clearance periods on 3 dogs (K6. K10 and K11) taken at 7 to 93 days after operation, D plasma clearance has averaged 141 cc/min./M2, where the normal was 258. The clearance of one completely hypophysectomized dog (K8) on the 4th postoperative day was 155, normal 222; a “simple hypophysectomy” dog (K9) on the 3rd day showed 191 cc/min./M2, where normal had been 208. One dog (K1), with a normal clearance of 232, had a unilateral nephrectomy on 7/22/40 and a simple hypophysectomy on 7/26/40; on 9/4/40 her D clearance was 107.
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