Some Factors Involved in the Assay of Renin

Abstract

Summary

The magnitude of the blood pressure rises given by large doses of renin must be corrected for differences in starting pressure levels, while those given by smaller doses need not be. An assay based on repeated tests on 2 or 3 dogs is as reliable as one based on a larger series of animals. Nembutal anesthesia may affect, in some dogs, the magnitude of the rise after large renin doses, but usually has little effect on the rise after small doses. For most routine testing, the anesthetized dog is the preferable test animal.