Abstract
Summary and Conclusions
The reactions of the guinea pig ileum to the toxic substance indicate that the latter is not histamine. It is, however, inactivated by histaminase suggesting that histaminase is not specific for histamine but may attack other substances. 2 Zeller has shown that histaminase is capable of hydrolyzing several diamine compounds other than histamine. 5
The toxic substance is destroyed by mild treatment with acid or alkali. However, heating at temperatures sufficient to denature proteins present failed to effect complete destruction of the toxicity. Treatment of the extract with both boiled and unboiled solutions of pancreatin discloses no destruction of the toxic substance by enzyme action.
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