Pharmacological Observations on Tetra-Sodium-2-Methyl-l,4-Naphthohydroquinone Diphosphoric Acid Ester

Abstract

Discussion and Summary

Although from the standpoint of treating prothrombin deficiencies lethal and sublethal doses of tetra-sodium-2-methyl-1,4-naphthohydroquinone diphosphoric acid ester are without practical significance, it is interesting to note their effects on the central nervous system. It seems likely that most of the peripheral effects observed are the result of central action but complete analysis of the manner of action has not yet been made. The anesthetic employed appears to possess a quantitative influence on the circulatory but not so much on the respiratory action. With ether anesthesia in cats there is less hypertension after substance N-123 than with Alurate anesthesia. The substance had very little influence on respiration in morphinized rabbits, but in cats under Alurate or ether anesthesia there was marked respiratory stimulation. As is true with most substances acting as biological catalysts (enzymes, vitamins, hormones) the safety margin of its antihemorrhagic effect is enormous. All doses are for the crystalline product containing a moisture equivalent of 6 molecules of water.