Antihemorrhagic Activity of Tetra Sodium 2-Methyl-1,4-Naphthohydroquinone Diphosphoric Acid Ester and Other Naphthoquinone Derivatives

Abstract

Summary

1. The CD50 (Thayer-Doisy unit) by subcutaneous administration of tetra sodium-2-methyl-1,4-naphthohydroquinone diphosphoric acid ester (C₁₁H₈O₈P₂Na₄ · 6H₂O)⁴ is 1.34 γ. 2. The subcutaneous CD50 of 2-methyl-1,4-naphthoquinone (C₁₁H₈O₂) is 0.64 γ.

3. The ratio of these potencies is 0.48 but on a molecular basis allowing for 6 molecules of water of crystallization the phosphoric ester is 50% more potent than methyl naphthoquinone.

4. Five naphthoquinone derivatives not hitherto reported are shown to be inactive in doses from 200 to 1000 γ.