Abstract
Summary
Leukemia appeared at an earlier age than in controls when mice of the F strain were painted twice weekly with methylcholanthrene. Myelogenous leukemia, which does not occur in untreated F mice before 300 days of age, appeared as early as 97 days after birth in treated mice. Only 3 cases of leukemia occurred in 184 mice of non-Ieukemic strains treated in a similar manner. The effectiveness of methylcholanthrene in influencing the appearance of leukemia in young mice depended on the genetic susceptibility of mice to the disease.
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