Effects of Progesterone Upon the Uterus of the Mouse. ∗

Abstract

Summary

With or without concomitant treatment with estrogen, the daily injection of 0.25 or 0.5 mg of progesterone into mice ovariectomized 3 weeks previously evoked mitosis in all the tunics of the uterus. The nuclei of the cells of the uterine tunica propria became larger and transformed from the fusiform, pyknotic type into vesicular nuclei. The latter condition was also seen in pregnant and lactating mice. Neither estrogen alone nor androgen provoked this morphology.