Excretion and Determination of Ginchophen in Bile

Abstract

Summary and Conclusions

A method for the quantitative determination of cinchophen in bile is described. In 5 anesthetized dogs weighing about 10 kilos, it was found that 20% of 1 g of intravenously injected cinchophen is excreted in the bile in 5 hours. In 4 “chronic” bile fistula dogs an average of 55%, or from 28 to 78%, of orally administered cinchophen (100 mg per kilo body weight) was daily excreted in the bile. This shows that the liver is significantly concerned in the excretion of cinchophen and that an enterohepatic circulation of cinchophen may occur. By weight sodium cinchophen increases the volume output of bile more than sodium dehydrocholate, which is an excellent hydrocholeretic. Cinchophen in large doses orally or intravenously decreases cholic acid output. But, it cannot be concluded from our results on “chronic” bile fistula dogs that cinchophen specifically interferes with cholic acid synthesis.