Abstract
Summary
The effect on liver metabolism of adding methylene blue, chloral hydrate and sodium barbital to serum has been studied. Methylene blue has been found to increase the oxygen consumption of rat liver respiring in human serum. Chloral hydrate and sodium barbital both depress the metabolism. Following depression of the oxygen consumption by chloral hydrate, methylene blue increases the metabolism. Following sodium barbital, the dye further depresses the metabolism. This is interpreted as indicating a difference in the site of action of the drugs on the oxidative system of the tissue cells.
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