Sulfanilamide,Sulfapyridine and Sulfathiazole and Experimental Infections in Mice Due to Shigella paradysenteriae Flexner

Abstract

Summary

All mice survived when fed, ad libidum, a complete diet containing 1 % of sulfathiazole for 2 or more days before and 7 days after injecting Shigella paradysenteriae Flexner. Seven of 18 mice survived when offered, ad libidum, 1% drug diets of sulfanilamide, sulfathiazole, and sulfapyridine immediately after injecting the organisms. Fifty-seven of 72 mice survived when given 4 feedings by stomach tube of these 3 drugs in doses varying between 2 mg and 1/10 mg. All of 72 mice survived when given 4 feedings of 2 mg of these 3 drugs by stomach tube, regardless of whether the first dose of drug was administered 2, 3, 4, or 5 hours after the injection of the organisms. Nine of 48 control mice survived.