Abstract
Summary
1. The immediate effect of morphine on colon motility resulting from the subcutaneous injection of ¼ grain is essentially a marked increase in the tone, with a diminution, frequently a disappearance of quiet periods. 2. Alternating with the periods of high tone is an exaggeration of Type I components of Type II contractions. 3. As far as the colon motility is concerned the dog shows no increased tolerance to ¼ grain of morphine given daily. 4. No evidence of a cumulative effect on colon motility was seen to follow daily injections of ¼ grain of morphine for a period of 60 days. 5. Twenty hours after subcutaneous injection of ¼ grain morphine the colon motility is practically the same as that prior to the injection.
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