Effect of Vitamin C on Creatine and Creatinine Metabolism

Abstract

Summary

In a case of glycogen disease, whose tolerance to creatine is known to be minimal, saturation with vitamin C caused a marked increase in the urinary excretion of creatine and creatinine. In 4 normal children and in a child with hypothyroidism, however, no significant increase was demonstrated. This is probably due to the fact that whatever increase in creatine formation due to the ingestion of ascorbic acid is covered by the normal capacity of storage. The mechanism of the action of vitamin C on creatine metabolism is not understood.