Coronary Occlusion. II. Efficacy of Papaverine Hydrochloride in Treatment of Experimental Cardiac Infarction

Abstract

Conclusion

The daily injection of papaverine hydrochloride (5 mg per kilo) into cats for 2 weeks did not alter significantly the size of the infarct resulting from the ligation of the left branch of the left anterior descending coronary artery. It is suggested that because of the greatly variable amount of cardiac tissue involved in each ligation this method of study is too crude to detect any “clinical” improvement that the drug may have exerted.