Abstract
Summary
P-Caproylaminobenzenesulfonhydroxamide produces bacteriostasis of pneumococci in blood without the lag characteristic of sulfanilamide. The activity is only about one-eighth of the corresponding bacteriostatic power in broth. That the immediate nature of the effect is due to the hydroxamide group was demonstrated by the use of p-toluenesulfonhydroxamide in which the potentially active p-amino group is absent. The effect of the hydroxamide group is transient in nature. A second period of bacteriostatic activity manifested by p-caproylaminobenzenesulfonhydrox-amide is probably due to the free amino group formed by deacylation of the caproylamino group.
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