Abstract
Summary
The administration of from 1 to 4 g of ascorbic acid per day has been found to be without effect on the excretion of homogentisic acid by an alkaptonuric individual excreting an average of 7 g of the metabolite daily. The ineffectiveness of this excessive amount of vitamin is a rinding which is in agreement with results with smaller doses obtained by other investigators.
The authors are indebted to Professor Vincent du Vigneaud for placing at their disposal laboratory facilities in the Department of Biochemistry of the Cornell University Medical College for the chemical work in connection with this experiment, and to Dr. Elaine P. Ralli of the Department of Medicine of New York University for the determination of the blood ascorbic acid.
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