Abstract
Summary
Toxic manifestations of staphylococci are not inactivated in vitro by sulfanilamide, sulfapyridine, or sulfathiazole. The lethal toxin, dermonecrotic toxin, coagulase, and enterotoxin are not neutralized by solutions of the sulfonamides tested at 37°C. α- and β-hemolysins are slightly diminished in activity at concentrations approaching the saturation point of the sulfonamides, but are unaffected at concentrations of less than .01%. These compounds appeared to decrease hemolysin production by decreasing the growth rate of the organism.
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