Diuretic Effect of Progesterone. ∗

Abstract

Summary

Progesterone increases the urine output both in normal and in hypophysectomized rats. Although the untreated hypophysectomized animal excretes less than the normal amount of urine, progesterone stimulates water excretion much more markedly in the absence than in the presence of hypophysis. In hypophysectomized rats, it may lead to the excretion of an amount of urine corresponding to 50% of the experimental animal's total body weight; a diuresis reminiscent of diabetes insipidus. The resistance of hypophysectomized animals to water intoxication is increased by progesterone.