Inhibition of Estrin-Deprivation Bleeding in Rhesus Monkey with Testosterone Derivatives Variously Administered. ∗

Abstract

Summary

1. Testosterone di-propionate prevented estrin-privea bleeding in daily parenteral doses of 5 mg in sesame oil. 2. Methyl testosterone inhibited estrin-privea bleeding when administered subcutaneously in the form of pellets or dissolved in sesame oil. Orally in daily doses of 10 mg, methyl testosterone prevented menstruation but otherwise failed to exert the slightest visible estro-genic effects. 3. Ethinyl testosterone prevented estrin-privea bleeding in the monkey when administered parenterally in doses of 5 mg a day. Given orally, it delayed slightly but did not prevent bleeding in daily doses of 20 mg, with no other estrogenic effects. 4. Testosterone propionate when administered orally in 20 mg doses along with bile salts, prevented estrin-privea bleeding, but otherwise its estrogenic effects proved minimal. 5. It is apparent that oral administration of any of the testosterone derivatives here tested is most uneconomical as compared with parenteral methods.