Effectiveness of Sulfanilamide upon Anaerobic Hemolytic Streptococci

Abstract

Summary

1. Two weakly virulent strains of “anaerobic,” Group A, hemolytic streptococci were subjected to in vivo and in vitro tests with sulfanilamide. 2. One strain was resistant, the other moderately susceptible, to the drug in mice. 3. No essential difference between the strains could be demonstrated, however, by in vitro bacteriostatic, phagocytic and biochemical tests. 4. Following adaptation to aerobic incubation (14 and 18 months) both strains were refractory in mice. 5. The results indicate that anaerobiosis, per se, was not the fundamental factor in determining drug response of these “anaerobic” hemolytic streptococci.