Reversibility of Digitalis Action. ∗

Abstract

Summary and Conclusions

1. In embryonic ventricles stopped by ouabain, tincture of digitalis, and digitoxin the effects of the drugs can be removed by washing with Tyrode solution. 2. Of the 3 glucosides, the action of digitoxin is the most difficult of removal. Tincture, in turn, is more difficult to remove than ouabain. 3. With tincture, the process of stop, wash-out, stop, wash-out, etc., can be repeated at least 6 times in the same ventricle. 4. Digitoxin-stopped ventricles recover in blood plasma and are indistinguishable as to function and structure from controls in the same medium.