Effects of Subcutaneous Injection of Estrogen upon Skeleton in Immature Mice

Abstract

Conclusion

Injections of estradiol benzoate into immature female and male mice in the dosages listed in the table, stimulate the proliferation of new bone in the medullary cavities of certain bones and especially of the lower end of the femur and upper end of the tibia. Other bones, including the calvarium, are also affected, but to a lesser degree. The proliferation begins around the zone of provisional calcification and advances into the diaphysial portion of the bone. The changes in question can easily be recognized on roentgenographic examination. When the pubic bones are involved, they undergo in addition, more or less resorption, the extent of which depends upon the dosage of estrogen and the duration of the experiment.