Action and Toxicity of Vitamin B 6 Hydrochloride

Abstract

Summary

1. Vitamin B₁ · HCI is acid in reaction which may be responsible for certain irritating effects in body tissues. 2. A method of bioassay has been described based upon the curing of rats' acrodynia. 3. The acute toxicity of B₆ · HC1 in mice and rats by intravenous injection has been determined. 4. Mice can tolerate repeated doses of 100 mg per kg, given intravenously, without pathological changes. 5. No ill effects occur in men when B₆ · HC1 is administered orally or intravenously in the dosage of 100 to 200 mg. Pain occurs when the drug is injected intramuscularly. 6. In the concentration of 1:8000, B₆ · HC1 inhibits isolated rabbit's small intestines, but contracts the isolated guinea pig's uterus.