Abstract
Summary
The acyl aminobenzenesulfonhydroxamides have strong anti-catalase activity and, when present in broth cultures of the pneumococcus, cause inhibition of growth associated with increased accumulation of hydrogen peroxide. When the caproyl compound is added to growing cultures, inhibition of growth is detectable almost immediately but reaches a maximum only after time for accumulation of peroxide has elapsed. Inhibition by sulfanilamide, on the other hand, is detectable somewhat later and approaches a maximum more slowly.
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