Abstract
Summary
A method is described of demonstrating the toxicity of urine by its effect on the growth rate of cell colonies in vitro. Normal human urine in a dilution 1:5 completely inhibits the growth of fibroblasts; urine in a dilution of 1:50 still perceptibly inhibits their growth. The cells growing in media containing urine even in small concentrations exhibit signs of degeneration. Heat does not destroy this property of urine. The toxic substance is nondialysable.
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