Abstract
Four adult dogs were given intraperitoneal injections of 2.5% dextrose and 0.9% NaCl solution in the dosage of 100 cc per kg. After 16 hours, 20 cc of blood were withdrawn from the femoral artery and 20 cc of fluid from the peritoneum. Previous observations 1 have revealed that the serum and peritoneal fluid Ca, Mg and P are in equilibrium at this time. Fifty cc of a 25% solution of MgSO4 were injected intramuscularly (3 cases) or subcutaneously (1 case). Blood and fluid samples (20 cc each) were obtained ½ 1,1/12; 2, 3, and 4/2 hours after injection of the MgSO4, and were examined for their Mg, Ca and inorganic P content.
Magnesium. The control values for serum Mg were 1.82-2.46 mg %. The maximum values after injection of magnesium ranged from 8.9 (subcutaneous injection) to 16.1 mg %, the peak being reached in 1-2 hours, with a subsequent decline.
The control values for peritoneal fluid Mg were 1.5-1.67 mg %. These increased in each instance, to values of 6.4-12.2 mg %, the peak being reached ½-1/12 hours after the peak of serum Mg concentration.
Calcium. The control serum calcium values were 9.45-12.1 mg %. These fell in each instance, to minimum levels of 6.39, 7.0, 7.6 and 8.92 mg %, the last in the animal injected subcutaneously. The maximum drop in serum Ca concentration (2.31-4.5 mg %) occurred ½-3/12 hours after the peak of serum Mg concentration.
The control values for peritoneal fluid Ca were 5.94-8.5 mg %. These changed relatively slightly during the experimental period, the range of maximum variation from the control values being +0.63 to -1.2 mg %, the latter occurring in the case in which the serum Ca concentration fell 4.5 mg %.
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