Abstract
Conclusions
It has been shown that the acute toxicity of sulfathiazole (as measured by the parenteral injection of sodium salts) for mice is one-third greater than that of sulfanilamide, and about half that of sulfapyridine, sulfathiazole methyl and sulfathiazole phenyl. Sulfathiazole is absorbed more readily and is excreted more rapidly than is sulfapyridine. Because of its rate of excretion it is probable that doses of sulfathiazole spaced at intervals of 4 hours will maintain adequate concentrations of the drug in the blood of patients.
We wish to thank E. R. Squibb and Son and the Calco Division of the American Cyanamid Company for supplying us with sulfathiazole, and the Department of Medical Research of the Winthrop Chemical Company, Inc., for supplying the sulfathiazole methyl and the sodium salt of sulfathiazole phenyl.
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