Abstract
Conclusions
Sulfathiazole is as effective a bacteriostatic agent as is sulfapyridine in broth cultures of certain strains of Lancefield's Groups A, D, and G beta hemolytic streptococci, E. coli, Staphylococcus aureus, Types I and II pneumococci and B. proteus. Under the conditions of our tests sulfathiazole was slighly less effective than sulfapyridine in the control of experimental pneumococcal infections in mice. However, as has been pointed out, the more rapid absorption and excretion of sulfathiazole by the mouse, partially invalidate the results of comparative therapeutic tests in which the drug is administered per os in acacia suspensions at stated intervals.
We wish to thank E. R. Squibb and Son and the Calco Division of the American Cyanamid Company for supplying us with sulfathiazole.
Get full access to this article
View all access options for this article.