Thiazol Derivatives of Sulfanilamide and Experimental Beta-Hemolytic Streptococcal and Pneumococcal Infections in Mice

Abstract

Conclusions

The chemotherapeutic effects of 3 thiazol derivatives of sulfanilamide under conditions of experimental streptococcal or pneumococcal infections are definitely superior to those of the parent substance and compare very favorably with those of sulfapyridine. On the basis of the superior margin of safety of sulfathiazol and particularly sulfamethylthiazol, as compared with sulfanilamide and sulfapyridine, these new compounds appear quite promising.