Abstract
Summary
The transplantability and rate of growth of a pure mammary fibroma were markedly enhanced by the presence of physiological levels of estrogens in the host rats. Physiological levels of androgens, however, had no demonstrable effect on this tumor. The tumor-stimulating effect of estrogen injections was greater in male castrates than in female castrates. With the onset of malignancy the connective tissue tumors lose their responsiveness to hormonal influences.
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