Abstract
Conclusions
The adrenal hypertrophy of normal and thyroidectomized rats has been shown to be directly proportional to the amount of adrenocorticotropic hormone administered. There was no evidence that the presence of the thyroid gland was necessary for the adrenal cortical hypertrophy produced by adrenocorticotropic preparations when given immediately after thyroidectomy. The administration of desiccated thyroid to normal rats did not augment the adrenal hypertrophy caused by adrenocorticotropic hormone. Further work will be necessary to determine whether or not a certain minimal amount of a thyroid principle is necessary in the production of adrenal hypertrophy.
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