Abstract
Conclusion
The above experiments show that anaerobic auto-lysis of renal cortex or cell-free cortical extract of the dog produces a powerful heat stable pressor substance that passes through a collodion membrane. This substance is not obtained from kidney medulla that has been subjected to the same conditions. Oxygen inhibits the formation of the pressor substance. The pressor action is manifest immediately after intravenous administration and it is greater and more sustained in hypertensive than in normal dogs. Increased quantities of pressor substance are produced as the anaerobic period is prolonged. The pressor substance is formed just as well in a substrate-free medium as in plasma.
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