Abstract
Previous experiments have shown that injected progesterone has been transformed into pregnandiol not only by women but also by men. 1 In pursuing this problem further, an attempt was made to find pregnandiol glucuronidate in the urine of experimental animals during normal cycles, during pregnancy and following injections of progesterone.
Urine was collected in metabolism cages and placed in the ice box with several drops of chloroform as a preservative. Examination for pregnandiol glucuronidate was then carried out on pooled specimens consisting of one or 2 liters of urine, according to the well proven method of Venning and Browne. 2 Urine from monkeys was collected from the first day of injection until 2 days after the last injection.
No pregnandiol glucuronidate was recovered in any instance. Also after hydrolysis no free pregnandiol was found in the monkey which received 80 mg of progesterone.
Table I shows the type and number of animals used.
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