Abstract
Conclusions
The data presented in this paper involving, (1) the use of approximately 300 animals, (2) 2 different transplantable tumors known as dbrB and New Buffalo Tumor, (3) the maintenance of the radiated tumor through the fourth transplant generation, are indicative of the fact that small doses of X-radiation are capable of producing a change in the genetic constitution of a tumor.
It is interesting to note in this connection that while X-rays have been used to produce mutative changes in certain forms of life, such as plants, insects and animals, the dosage required for these changes is far in excess of that which we used to produce changes in the constitution of the tumors.
As shown by Muller and others, thousands of roentgens are needed to produce mutations and the higher the dosage the greater is the mutational effect. In our experience we have been unable to distinguish any quantitative difference between doses of 50 r and 100 r. Doses of 1500 r cause regression.
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